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Fighting Disease With Breath Biopsies: Lower Risk & Lower Cost

by | Dec 5, 2023 | Medical Device & Diagnostic

A Breath of Fresh Air for Diagnostics 

A diagnosis may be as simple as breathing! A breath biopsy is a diagnostic method that analyzes the volatile organic compounds (VOCs) in a person’s breath to detect diseases. Think of it as a “disease breathalyzer.”

Mile High

The complete set of biochemical reactions our cells use to create energy is called cellular metabolism. 

Byproducts of cellular metabolism are organic compounds that contain carbon. They empty into our bloodstream and are expelled from our lungs when we exhale. Scientists refer to the stuff we breathe out as volatile organic compounds (VOCs) or metabolites.

VOCs can indicate metabolic changes in the body, which appear before other disease symptoms. Detecting these changes can lead to early diagnosis and more effective treatment.

Why it Matters

The earlier a doctor can detect an illness, the more likely a good outcome, saving patient’s time, money, and grief. 

Breath biopsies are non-invasive, painless, highly sensitive, and capable of detecting minute concentrations of suspicious VOCs. Breath biopsies can detect disease before symptoms occur. 

Applied Science

Cancer cells consume glucose two hundred times faster than healthy cells. Malignant cells also use anaerobic (without oxygen) metabolic pathways rather than aerobic (with oxygen) pathways preferred by healthy cells. The glucose use and alternative metabolic pathways create different byproducts detected as VOCs. 

Other diseases that produce altered VOCs include diabetes, liver impairment, kidney disease, asthma, cystic fibrosis, rheumatoid arthritis, atherosclerosis, and tuberculosis.

Diagnostic Development Primer

Around the Bend

Owlstone Medical (Cambridge, U.K.) is developing a diagnostic based on VOCs with their ReCIVA Breath Sampler. 

Breath biopsies aren’t yet available as a diagnostic tool. Owlstone Medical is currently running the following trials to demonstrate what a breath biopsy can do in action:

Not so Easy

Bringing a breath biopsy diagnostic to the marketplace is not easy. However, learning the approval pathway is easy when you have Biotech Primer’s Diagnostic Development Primer 40-minute class helping you navigate the complex world of FDA regulations.

Cocktail Fodder

Dogs can sniff out some kinds of cancer.  Canine noses contain 220 million scent receptors, which scientists have found are sensitive to VOCs in our breath, sweat, saliva, and urine.

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