BioImmersion™ is a three-day, in-depth course that provides the background required for understanding today’s fast-paced biotech marketplace. Beginning with an overview of the basic science needed to understand new drug discovery and development, the course emphasizes healthcare applications. Confused about the exact differences between a small molecule and large molecule drug? Want to learn more about the science behind buzz words like “RNA therapeutics,” “CAR-T,” “immune checkpoint inhibitors,” and “biosimilars?” Curious about the exploding applications of next-generation sequencing technology in the personalized medicine space?  For all of this and more, we’ve got you covered. You will leave with a comprehensive understanding of how the technologies driving the industry come together to deliver new products.

Day One

Industry Overview 9:00-10:30
Biotechnology Defined
Industry Sectors: Healthcare, Agriculture, Industry & Environment
Small Molecule Drugs
Large Molecule Drugs
Peptide Drugs
Generics & Biosimilars
Research Support Companies and Contract Research Organizations
The Intersection of Academia & Industry

Break 10:30-10:45

Biology Basis of Biopharma 10:45-noon
Biotechnology Goals
Cell Structure & Function
Molecules Critical to Life
Proteins: Critical to Cellular Function
Cellular Communication: Cell Signaling Pathways
Industry Application: Antagonists & Agonists as Drugs
Activity: DNA Isolation & Extraction

Lunch provided noon-1:00

DNA: Biopharma’s Blueprint 1:00-1:30
The History of DNA Discovery
DNA Structure & Function
DNA Replication
DNA Amplification: PCR
Chromosomes & Genes

Proteins: Biopharma’s Workhorse 1:30-2:30
How DNA Codes for Proteins
Protein Structure
Post-Translational Modifications
Post-Translational Modifications: Critical to Making Biologics
Protein Folding
Chaperone Therapeutics
Industry Application: The Proteome and Drug Discovery

Genetic Basis of Disease 2:45-4:15
Alleles
Dominant & Recessive Diseases
Mutations: The Source of Genetic Variation
Genetic Basis of Disease
Genome-Wide Association Studies
Stratified Medicine & Companion Diagnostics
Pharmacogenomics
Activity: Genetic Taste Test

Q&A|Review 4:15-4:30

Day Two

Genomics: Understanding the Genetic Basis of Disease 9:00-10:30
Genomics Defined
Non-Coding DNA: The Regulome
DNA Microarrays (Gene Chips)
Applications of DNA Microarrays
Next Generation Sequencing
Applications of Next Generation Sequencing
From Big Data to Rare Disease
Third Generation Sequencing
Personalized Medicine: Integrating the ‘Omics
Comparative Genomics
Activity: Microarray to Determine Drug Metabolism

Break 10:30-10:45

Treating Genetic Disease 10:45-noon
RNA Therapeutics (Antisense, siRNA, microRNA, mRNA)
Changing Gene Expression: Exon Skipping Therapy
Gene Therapy
Viral Vectors Used in Gene Therapy
Genome Editing: Zinc Finger Nuclease
Genome Editing: Curing HIV?
Genome Editing: CRISPR/CAS9

Lunch provided noon-1:00

Immunology & Infectious Disease 1:00-2:15
Cells and Tissues of the Immune System
Phases of the Immune Response
Non-Specific Immune Response: Inflammation
Industry Application: Understanding Autoimmune & Inflammatory Disease
Specific Immune Response: T-Cells & B-Cells
Antibodies: Structure & Function
Cytotoxic T-Cell Structure & Function
Helper T-Cell Structure & Function

Break 2:15-2:30

Activating an Immune Response: Vaccines 2:30-3:00
Immunological Memory
How Vaccines Work
Types of Vaccines: Whole Pathogen, Subunit, and DNA
Making the Annual Flu Vaccine
Towards a Universal Flu Vaccine
Industry Application: Oncolytic Vaccines
Industry Application: Developing an HIV Vaccine

Immunotherapies: Biopharma’s Therapeutic Powerhouse 3-4:15
Polyclonal vs. Monoclonal Antibodies
Making Therapeutic Antibodies (Hybridomas, Phage Display, Genetically Engineered Mice)
Humanized vs. Fully Human Antibodies
Therapeutic Monoclonal Antibodies For: Oncology, Autoimmune Disorders, Infectious Disease
Indsutry Application: Treating Cholesterol with PCSK9 Inhibitors
Bispecific Antibodies
Antibody-Drug Conjugates
Immune System Checkpoint Inhibitor Therapies
Chimeric Antigen Receptor Therapies (CAR-T)
Controlling CAR-T
TCR Therapies

Q&A|Review 4:15-4:30

Day Three

Making Biologics 9:00-10:15
Biologics vs. Small Molecule Drugs
Recombinant DNA
Plasmids
Production Platforms: Bacterial & Mammalian Cells
Production Platforms: Animals & Plants
Fusion Protein Therapeutics
Biosimilars: Definition & Approval Pathway
Patents & Data Exclusivity

Break 10:15-10:30

Biomanufacturing 10:30-11:30
Cell Line Development
Cell Bank Production & Qualification
Bulk Upstream Process: Harvest & Purification
Product Purification: Column Chromatography
Formulation, Fill & Finish
Activity: Column Chromatography

Stem Cells & Regenerative Medicine 11:30-12:30
Properties of Stem Cells
Promises & Challenges
Induced Pluripotent Stem Cells
Stem Cells in the Clinic
Organ & Tissue Replacement

Lunch provided 12:30-1:30

Drug Development 1:30-2:30
Rational Drug Discovery
Target Identification & Validation
Therapeutic Options
Assay Development & High Throughput Screening
In Vitro Safety & Efficacy Testing
Biomarkers

Break 2:30-2:45

Drug Development 2:45-3:45
Regulatory Agencies
Preclinical & Clinical Trials
Pharmacovigilance
Drug Development Timeline
Desirable FDA Designations
Orphan Drugs

Newly Approved and In Development 3:45-4:15
Microbiome & Related Therapies
Circulating Tumor Cells: Detection & Capture
Curing Hepatitis C
Liquid Biopsies
Exosome-Based Therapeutics
Epigenetic Medicine & Diagnostics
Overcoming Antibiotic Resistance: Bacteriophage

Wrap Up 4:15-4:30